Download An Omics Perspective on Cancer Research by William C. S. Cho (auth.), William C.S. Cho (eds.) PDF

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By William C. S. Cho (auth.), William C.S. Cho (eds.)

Omics is an rising and intriguing quarter within the box of technology and drugs. a variety of promising advancements were elucidated utilizing omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in melanoma study. the improvement of high-throughput applied sciences that let the answer of decoding melanoma from greater dimensionality will supply a data base which adjustments the face of melanoma realizing and therapeutics.

This is the 1st booklet to supply one of these complete assurance of a speedily evolving sector written by means of prime specialists within the box of omics. It complies and info state-of-the-art melanoma examine that covers the wide advances within the box and its program from cancer-associated gene discovery to drug goal validation. It additionally highlights the potential for utilizing integration technique for melanoma research.

This specified and well timed ebook presents a radical review of constructing omics, with a view to attract a person eager about melanoma study. it will likely be an invaluable reference booklet for graduate scholars of alternative matters (medicine, biology, engineering, and so forth) and senior scientists drawn to the attention-grabbing zone of complex applied sciences in melanoma research.

Readership: this can be a important booklet for every type of readers – melanoma researchers, oncologists, pathologists, biologists, scientific chemists, pharmacologists, pharmaceutical experts, biostatisticians, and bioinformaticists who are looking to extend their wisdom in melanoma research.

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Extra resources for An Omics Perspective on Cancer Research

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S. V. A. Klomp et al. oligonucleotide sequences (probes) that have been arrayed onto a solid substrate (the gene expression “chip”). Complementary oligonucleotide probes are designed to hybridize with high affinity to the RNA produced by individual genes. During chip construction, photolithographic or fine-liquid handling techniques are used to deposit these gene-specific oligonucleotide probes in precise locations on the solid surface. Since the surface area required by the probes is very small, thousands to millions of unique probes can be arrayed on a single chip.

While the complications of technical or experimental error coupled with the stochastic nature of gene expression may limit the understanding of all of the experimental variation, it will be crucial to categorize as much gene expression variability as possible. References Alizadeh AA, Eisen MB, Davis RE et al (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403:503–511 Alon U, Barkai N, Notterman DA et al (1999) Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays.

Proc Natl Acad Sci USA 102:3738–3743 Chen X, Cheung ST, So S et al (2002) Gene expression patterns in human liver cancer. Mol Bio Cell 13:1929–1939 Chi JT, Wang Z, Nuyten DS et al (2006) Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med 3:e47 Choe SE, Boutros M, Michelson AM et al (2005) Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset. Genome Biol 6:R16 Choi K, Creighton CJ, Stivers D et al (2007) Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations.

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