Download Antioxidants in Biology and Medicine: Essentials, Advances, by Professor and Chair Dr Yunbo Li PDF

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By Professor and Chair Dr Yunbo Li

It is a booklet that takes a distinct method of integrating wisdom in antioxidants from necessities to advances, and from uncomplicated learn to medical functions. This e-book offers clinical info on antioxidants in an organised, cogent, and in-depth demeanour. The constant layout of writing, the full-colour illustrations, and the excellent checklist of references make the ebook available and fascinating. in addition to its price as a textbook for undergraduate and graduate scholars in existence technology, "Antioxidants in Biology and medication" can also be an invaluable reference for biomedical study scientists, clinicians, and different wellbeing and fitness pros.

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Animal Studies on Antioxidant-based Disease Intervention Animal studies provide important information on the safety and efficacy as well as mechanisms of actions for drugs that are used for the prevention and treatment of human diseas- Introduction to Antioxidants 27 es. This is also true for the development of antioxidant-based strategies for the intervention of disease conditions involving an ROS/RNS-mediated pathophysiological component. Three approaches as outlined below are commonly used to study antioxidant intervention of diseases in experimental animals.

Another approach of clinical potential in humans is gene therapy. Gene therapy with the use of antioxidant genes is emerging as a promising approach for select disease conditions and is an especially lucrative option for patient groups not suitable for conventional therapies [8]. However, this approach is much limited in human studies due to safety concerns. 2. Genetic Variation Studies The discovery in 1993 of the Cu,ZnSOD mutations in familial amyotrophic lateral sclerosis, a fatal, adult-onset neurodegenerative disease primarily affecting motor neurons, has attracted broad attention on the biological role of SODs in human disorders [44].

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. 1995;11:376-381. Vincent AM, Russell JW, Sullivan KA, Backus C, Hayes JM, McLean LL, et al. SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy. Exp. Neurol. 2007;208:216-227. Shen X, Zheng S, Metreveli NS, Epstein PN. Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy. Diabetes 2006;55:798805. Kowluru RA, Kowluru V, Xiong Y, Ho YS.

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